中药抗炎活性成分研究进展

摘要

中药在抗炎药物的研究中，因其药效好，来源丰富，不良反应少而受到人们关注和重视，中药抗炎活性成分结构类型广泛，目前已经从机体水平、细胞水平、分子生物学水平、基因水平上阐述了各类中药活性成分的抗炎作用机制，而中药抗炎作用的分子机制十分复杂，中药是通过多途径、多环节发挥抗炎作用的，必须从更多的抗炎途径和环节对其进行深入研究。目的：综述了近年来中药活性成分对炎症有较好的治疗作用的研究进展。方法：检索近年来国内相关文献并进行了分析和归纳。我国传统中药抗炎的效果是肯定的，相比起西药较大的不良反应，中药还有其独特优点。中药抗炎活性成分来源丰富、不良反应小，原料易得，具有广泛的应用开发前景。结论：通过对中药活性成分的抗炎作用及其作用机制的研究，可为进一步研究与开发中药抗炎新药提供信息。

关键词　中药；药理活性；抗炎作用

目    录

摘要······························································1

一、中药活性成分概述············································2

（一）中药活性成分内容·······································2

1.中药抗炎与免疫功能····················································2

   2.中药抗炎分子作用机制·················································2

   3.中药抗炎与细胞因子···················································3

4.黏附分子······························································3

5.核因子································································3

6.氧自由基······························································3

（二）抗炎活性成分对炎症模型作用·························· 4

二、 抗炎活性成分分析··········································5

  （一）生物碱·················································· 5

  （二）萜类·····················································5

（三）黄酮类··················································6

（四）简单芳香化合物········································ 7

（五）香豆素类 ···············································8

三、中药抗炎活性药理研究········································10

（一）青风藤抗炎活性药理····································10

（二）青风藤抗炎镇痛与免疫抑制作用························10

四、细胞分子水平的抗炎免疫药理机制···························11

（一）特异性免疫·············································11

（二）非特异性免疫···········································11

五、案例研究·····················································12

（一）中药地龙活性成分······································12

（二）药理作用·················································13

六、结轮··························································14

参考文献 ························································15 致谢····························································· 17