强心苷药物的心脏毒性及其代谢机理研究

摘要

随着世界医疗水平的发展，强心苷类药物的毒性逐渐为人们所重视。强心苷类药物是一类具有强心效果的甾体类化合物，其主要运用与临床治疗心力衰竭、心功能不全、心律失常等，并且在临床应用上有着不可取代的地位。但由于强心苷类药物的毒性，特别是心脏毒性对患者的巨大危害，强心苷类药物的临床应用风险较高。因而，本文通过对强心苷类药物的心毒性及代谢途径进行研究，进而确定强心苷类药物的心毒性与代谢之间的关系，为强心苷类药物的临床安全应用提供参考。

关键词　强心苷；心毒性；代谢机制

Abstract

With the development of medical standards in the world, the toxicity of cardiac glycosides has gradually gained attention. Cardiac glycosides are a class of steroidal compounds with strong cardiac effects. They are mainly used for clinical treatment of heart failure, cardiac insufficiency, arrhythmia, etc., but due to the toxicity of cardiac glycosides, especially cardiotoxicity The great harm of patients, the risk of clinical application of cardiac glycosides is higher. Therefore, this paper studies the cardiotoxicity and metabolic pathways of cardiac glycoside drugs, and then determines the relationship between cardiotoxicity and metabolism of cardiac glycosides, and provides reference for the clinical safety application of cardiac glycosides.

Keywords　 Cardiac glycoside; Cardiotoxicity; Metabolic Mechanism

目录

摘要 I

Abstract II

引言..............................................................................................................................III

第一章.绪论 1

1.1 研究意义 1

1.2 研究方法 1

第二章.强心苷的药理作用及作用机制 2

2.1强心苷的药理作用 2

2.1.1正性肌力作用 2

2.1.2负性频率作用 2

2.1.3电生理特性及心电图影响 2

2.2强心苷的作用机制 3

致谢.............................................................................................................................11