非甾体抗炎药物临床活性的研究

摘要

非甾体抗炎药(Non-Steroidal anti-inflammatory drugs, NSAIDs)是目前用量最大的—类药物之—。它们的作用机制及药理作用基本相同,即抑制环氧化酶(COX)的合成,由于COX能催化花生四烯酸转化为前列腺素(P)G,故Cox被抑制后,GP的合成亦被抑制,GP(尤其是PGGZ和PGE:)是体内的致炎物质和疼痛的重要介质。故非甾体抗炎药类药物均有抗炎、镇痛作用。

非甾体类抗炎药物在针对临床患者治疗中可产生不同程度的抗炎以及镇痛效果，其镇痛主要作用于外周，在内脏疼痛以及创伤诱发的剧烈疼痛中的应用效果较差。对于关节肌肉的疼痛以及术后镇痛效果极佳。其主要作用原理为药物应用后可产生对前列腺素起到抑制合成作用的物质，同时其对淋巴细胞具有—定的抑制性，阻碍其分化增殖，从而降低对神经末梢的有效刺激。另外其还可作用于相关感受器，对致痛物质的形成起到—定的阻碍作用。从而降低疼痛的发生。除镇痛外，其消炎作用显著。非甾体类抗炎药物可有效抑制白细胞聚集，缓激肽的相关作用受到抑制，同时阻止血小板凝集，起到有效的抗炎作用。

 

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs. Their mechanism of action and pharmacological effects are basically the same, that is, inhibition of cyclooxygenase (COX) synthesis, because COX can catalyze the conversion of arachidonic acid to prostaglandin (P) G, so Cox is inhibited, GP synthesis Inhibition, GP (especially PGGZ and PGE) is an important mediator of the body's inflammatory substances and pain. So non-steroidal anti-inflammatory drugs are anti-inflammatory, analgesic effect.

Non-steroidal anti-inflammatory drugs in the treatment of clinical patients can produce varying degrees of anti-inflammatory and analgesic effect, the analgesic effect mainly in the periphery, in visceral pain and trauma induced severe pain in the application of poor results. For the joint muscle pain and postoperative analgesic effect is excellent. The main role of the principle of drug applications can produce prostaglandins play a role in inhibiting the synthesis of substances, while its lymphocytes have a certain inhibitory, hinder its differentiation and proliferation, thereby reducing the effective stimulation of nerve endings. In addition it can also act on the relevant receptors, the formation of pain-causing substances play a role in the set. Thereby reducing the incidence of pain. In addition to analgesic, the anti-inflammatory effect is significant. Non-steroidal anti-inflammatory drugs can effectively inhibit leukocyte aggregation, bradykinin-related effects are inhibited, while preventing platelet aggregation, play an effective anti-inflammatory effect.

目录

摘要 I

Abstract II

1绪论 1

1.1研究背景 1

1.2研究目的和意义 1

2文献综述 1

3本文主要研究内容 2

3.1非甾体抗炎药物的概念 2

3.2非甾体抗炎药物的检测方法 3

3.3临床中对非甾体抗炎药物的运用 4

4非甾体抗炎药物临床反应的研究 5

4.1非甾体抗炎药在临床中的不良反应 5

4.2非甾体抗炎类药物治疗炎症的优势 6

结论与建议 8

参考文献 9

致谢 10